Endocrine Abstracts

Introduction: The majority of adrenal neoplasms are benign while adrenocortical carcinomas (ACC) are rare with poor prognosis. Previous studies indicated that estrogens play important role in the etiology and progression of adrenocortical tumors. Estrogens exert genomic activities trough the estrogen-receptor (ER) subtypes α and β, while the non-genomic effects are mediated by membrane-bound-G-protein-coupled-ER-30 (GPR30). Although estrogens induce cancer cell ...

Aims: Liraglutide 3 mg once daily is an approved, prescription injectable Glucagon Like Peptide-1 receptor agonist that, when used with a low-calorie diet and increased physical activity, can reduce excess weight in patients with obesity. MiRNAs are small non-coding single stranded RNAs that regulate gene expression post-transcriptionally by inhibiting their mRNA target translation into proteins. MiRNAs can be secreted in the blood stream and affect the molecular pathways...

Background: Congenital hypogonadotropic hypogonadism (CHH), a clinically and genetic heterogenous sydrome, is caused by > 40 known loci whose mutations share the ability to cause defects in the ontogeny of the GnRH neuron network leading to absent/incomplete puberty and infertility. Cornelia de Lange Syndrome (CdLS) is similarly heterogenous disorder (distinctive facies, psychomotor delay, growth retardation and upper limb malformation) caused by mutations in 7 different g...

Introduction: The prevalence of cardiovascular disease in reproductively active women has received limited attention. Recent data indicated possible adverse effect of non-typical obstetrical risk factors with regards to cardiovascular function. We aimed to evaluate the potential association between anti-mullerian hormone (AMH), a known marker of ovarian reserve, with subclinical atherosclerosis in young premenopausal women.Methods: This was a cross-secti...

Introduction: The aim of this study was to investigate the association between the genetic background of coagulation factors and the presence of oligo- or amenorrhea in adolescent girls diagnosed with anorexia nervosa compared with controls.Patients and Methods: A total of 40 adolescent girls diagnosed with anorexia nervosa aged 14–17 years, as well as 10 age-matched girls, were included in the study. We recorded anthropometric parameters and calcu...

Introduction: The National Osteoporosis Guideline Group (NOGG) recommends determine BMD in patients who present an intermediate risk of osteoporotic fracture using the FRAX® tool, follow-up for low risk, and treatment for high risk. In 2011, 3163 BMD were performed in the Complejo Asistencial Universitario de León (CAULE). Since the cost for each BMD is 58.6* (BOCYL 31/01/2011), annual spending could rise to *185 352. The aim was to assess whether fracture risk calcu...

Introduction: Thyroid dysfunction, whether overt or subclinical, has a significant effect on the cardiovascular system. On the other hand, fluctuation of thyroid hormones within the normal range has been associated with long-term health risks, and might have an impact on the vasculature. This study assessed the effect of thyroid hormones on surrogate markers of arterial structure and function in a sample of euthyroid postmenopausal women.Methods: This cr...

Background: Non-alcoholic fatty liver disease (NAFLD) is a very common liver disorder associated with insulin resistance and the metabolic syndrome. Insulin resistance is also a prominent feature even in lean women with the polycystic ovarian syndrome (PCOS). The objective of this study was to identify the presence of NAFLD in young lean women with PCOS.Methods: Fifteen women with PCOS and 10 controls participated in the study.Mean...

Background: Infertility is a common problem and the number of couples receiving assisted reproductive treatment (ART) is increasing. Using GnRH agonists (GnRHa) to trigger oocyte maturation has been shown to reduce risk of ovarian hyperstimulation syndrome (OHSS), a common complication of IVF, compared to the more traditional use of human chorionic gonadotropin (hCG). Kisspeptin has recently been shown to be a safe trigger of oocyte maturation in women at high risk of OHSS. Ki...

Introduction: Treatment with sodium glucose co-transporter2(SGLT2) inhibitors was found to reduce the incidence of cardiovascular events in diabetic patients.Herein, we investigated the effects of long-term treatment with canagliflozin on atherosclerosis development in the aorta of Apolipoprotein E knockout (Apo-E(−/−)) mice as well as on biochemical and immunohistochemical markers related to atherosclerosis.Methods: At 4 weeks of ...